Lectures
Initial lectures will be used to introduce the topic
Readings
Readings are assigned on a weekly basis.
Presenters
ONLINE VERSION: Groups will complete an online video and turn it in using CANVAS
- Week 1 Getting Set Up
- Metabolic Brain Disorders-Boyle
- Video - Lecture: Overview of the course
- Class Syllabus
- Video - Lecture: Introduction to the course and syllabus.
- Mind Maps - Extra Credit Opportunity
- How to Read A paper
- How To Write a Scientific Review
- Here is an example of a great presentation ;-)
- Week 1 Recommended Papers of Interest
- Autonomic regulation of islet hormone secretion- implications for health and disease-2000.
- Mechanisms for Insulin Resistance- Common Threads and Missing Links
- Alterations of insulin signaling in type 2 diabete- A review of the current evidence from humans
- Ch15-Insulin Resistance, Metabolic Syndrome, and Therapy
- Week 1 Focus and Quiz Paper
- Insulin - An Introduction
- Focus: Autonomic regulation of islet hormone secretion- implications for health and disease-2000.
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- Week 2 Mentor Group Formation
- Insulin Basics - Lecture Notes
- Video - Lecture: Insulin Basics (a)
- Video - Lecture: Insulin Basics (b)
- Video - Lecture: Insulin Basics (c)
- Insulin Signaling - Lecture Notes
- Video - Lecture: Insulin Signaling
- Insulin Signaling (IRS)- Lecture Notes
- Video - Lecture: Insulin Signaling (IRS)
- Insulin Resistance - Lecture Notes
- This Is How I Will Reverse Type 2 Diabetes
- Do Australians Need a Sugar Intervention? --NYT-Documentary Video.
- In Asia's Fattest Country, Nutritionists Take Money From Food Giants - NYT 2017.
- In Sweeping War on Obesity, Chile Slays Tony the Tiger -- NYT 2017.
- One Man's Stand Against Junk Food as Diabetes Climbs Across India -- NYT 2017
Interesting Articles in the News:
- Week 2 Recommended Papers of Interest
- The role of insulin receptor signaling in the brain-2005.
- Interactions between the central nervous system and pancreatic islet secretions: a historical perspective-2013.
- The Metabolic Syndrome - Endocrine Reviews 2008
- A Comprehensive Review on Metabolic Syndrome - Kaur 2014.
- Alzheimer's Disease Is Type 3 Diabetes–Evidence Reviewed - de la Monte 2008
- Week 2 Focus and Quiz Paper
- Insulin Signaling Pathways
- Focus: The role of insulin receptor signaling in the brain-2005.
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- Week 3 Presentations
- Boyle - Lecture Notes: Introduction to Leptin
- Video - Lecture: Introduction to Leptin
- Week 3 Recommended Papers of Interest
- Intracellular signalling pathways activated by leptin
- Ch4-Insulin-Leptin Signaling in the Brain
- Obesity and Leptin Resistance Distinguishing Cause from Effect-2010
- Leptin Engages a Hypothalamic Neurocircuitry to Permit Survival in the Absence of Insulin-2013
- 20 YEARS OF LEPTIN_ Human disorders of leptin action
- Leptin Signaling-F1000-2014
- The endocannabinoid system directing eating behavior and macronutrient metabolism-2015
- Endocannabinoids An appetite for fat-PNAS-commentary-2011
- Cannabimimetic phytochemicals in the diet – an evolutionary link to food selection and metabolic stress adaptation-2017
- Endocannabinoid signal in the gut controls dietary fat intake-pnas-2011
- Week 3 Focus and Quiz Paper
- Introduction to Leptin
- Focus: Intracellular signalling pathways activated by leptin
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- Week 4 Recommended Papers of Interest
- Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin-2014
- Ghrelin mediates stress-induced food-reward behavior in mice
- Ch29-Ghrelin, Lipid Metabolism and Metabolic Syndrome.
- Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women-2014
- High-fat diet increases ghrelin-expressing cells in stomach, contributing to obesity-2016
- Linking Stress and Infertility A Novel Role for Ghrelin-2017-Review
- A ghrelin–growth hormone axis drives stress-induced vulnerability to enhanced fear-2014
- Addiction and Ghrelin Review.
- FGF21 Regulates Sweet and Alcohol Preference
- FGF21 and metabolic disease in 2016 A new frontier in FGF21 biology-2016
- Blaming the Brain for Obesity Integration of Hedonic and Homeostatic Mechanisms-2017
- Week 4 Focus and Quiz Paper
- Neonatal Overnutrition and Ghrelin
- Focus: Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin-2014
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- Week 5 Presentations
- Week 5 Recommended Papers of Interest
- The role of leptin in Anorexia Nervosa-Clinical implications.
- Leptin, Nutrition, and the Programming of Hypothalamic Feeding Circuits
- Anorexia nervosa-PRIMER.
- Adiponectin receptors: A review of their structure, function and how they work.
- You are what you secrete.
- The role of adipokines in skeletal muscle inflammation and insulin sensitivity.
- Nutritional programming of hypothalamic development-critical periods and windows of opportunity.
- Developmental programming of hypothalamic neuronal circuits: impact on energy balance control.
- Increased Adiposity in Adults Born Preterm and Their Children.
- Relationship Between Feeding and Early Stress in Premature Infant: The Role of Epigenetic Factors.
- Week 5 Focus and Quiz Paper
- Adiponectin Introduction to their structure and function.
- Focus: Adiponectin receptors: A review of their structure, function and how they work.
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- Week 6 Presentations
- Exercise May Help to Fend Off Depression-2019 NYT
Interesting Articles in the News:
- Week 6 Recommended Papers of Interest
- Exercise-Released Myokines in the Control of Energy Metabolism
- Chronic Inflammation in Obesity and the Metabolic Syndrome
- Obesity and inflammation-the linking mechanism and the complications.
- Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.
- Inflammation and insulin-IGF-1 resistance as the possible link between obesity and neurodegeneration.
- Insulin resistance in the brain- An old-age or new-age problem?
- Exercise-induced myokines in health and metabolic diseases
- The role of exercise-induced myokines in regulating metabolism
- Adipokines and Myokines-A Pivotal Role in Metabolic and Cardiovascular Disorders
- Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease
- Week 6 Focus and Quiz Paper
- Myokines and Metabolism Control
- Focus: Exercise-Released Myokines in the Control of Energy Metabolism.
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- Week 7 Presentations
- The Germs That Love Diet Soda-2018 NYT
Interesting Articles in the News:
- Week 7 Recommended Papers of Interest
- The Gut Immune Barrier and BBB-Are they so different?
- Feeding the microbiota-gut-brain axis: diet, microbiome, and neuropsychiatry
- Stress & the gut-brain axis: Regulation by the microbiome
- The association between neonatal vitamin D status and risk of schizophrenia
- Metabolic Syndrome, Alzheimer Disease, Schizophrenia and Depression: Role for Leptin, Melatonin, Kynurenine pathways, and Neuropeptides.
- Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder
- Did Acetaminophen Provoke the Autism Epidemic
- Evidence the U.S. autism epidemic initiated by acetaminophen (Tylenol) is aggravated by oral antibiotic amoxicillin/clavulanate (Augmentin) and now exponentially by herbicide glyphosate (Roundup)
- Acetaminophen Use in Pregnancy and Neurodevelopment-Attention Function and Autism Spectrum Symptoms
- The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism
- Week 7 Focus and Quiz Paper
- The Gut and the Blood Brain Barrier
- Focus: The Gut Immune Barrier and BBB-Are they so different?
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- Week 8 Presentations
- How a Low-Carb Diet Might Aid People With Type 1 Diabetes-2018 NYT
Interesting Articles in the News:
- Week 8 Recommended Papers of Interest
- Do ketone bodies mediate the anti-seizure effects of the ketogenic diet.
- Insulin Peptides as Mediators of the Impact of Life Style in Alzheimer's disease
- Ketogenic diets and Alzheimer’s disease.
- Ketogenic diet treatment in adults with refractory epilepsy
- The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet
- Sleep Disturbances, Body Mass Index, and Eating Behavior.
- Daily Rhythms of Hunger and Satiety in Healthy Men during One Week of Sleep Restriction and Circadian Misalignment.
- Melatonin in type 2 diabetes mellitus and obesity.
- The Role of Sleep in the Control of Feeding Behavior
- The metabolic burden of sleep loss.
- Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance randomized trial.
- The Carbohydrate-Insulin Model of Obesity Is Difficult to Reconcile With Current Evidence.
- Critical ReviewKetone Bodies Mimic the Life Span ExtendingProperties of Caloric Restriction.
- Week 8 Focus and Quiz Paper
- Ketone Bodies, Insulin and Alzheimer's Disease
- Focus: Do ketone bodies mediate the anti-seizure effects of the ketogenic diet.
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- Week 9 Presentations
- Week 9 Recommended Papers of Interest
- Sleep Control, GPCRs, and Glucose Metabolism
- Sleep, circadian rhythms and Alzheimer Disease
- Glucose Regulates the Release of Orexin-A from the Endocrine Pancreas
- A Decade of Orexin-Hypocretin and Addiction Where Are We Now-2017
- Microbes and Alzheimer’s Disease-2016
- Herpes simplex virus type 1 and Alzheimer’s disease: increasing evidence for a major role of the virus.
- HSV-1 and Alzheimer’s disease-more than a hypothesis-2014
- Endocytic vesicle rupture is a conserved mechanism of cellular-2017
- Sleep, circadian rhythms, and the pathogenesis of Alzheimer Disease
- Sleep Derives Metabolite Clearance from the Adult Brain
- The Glymphatic System A Beginner's Guide-2015
- The Glymphatic System in Central Nervous System Health and Disease Past, Present, and Future
- Week 9 Focus and Quiz Paper
- Sleep Control and your Metabolism
- Focus: Sleep Control, GPCRs, and Glucose Metabolism
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- Week 10 Presentations
- Week 10 Recommended Papers of Interest
- Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus-2016
- Clinical Review of Antidiabetic Drugs Implications for Type 2 Diabetes Mellitus Management
- Skin autofluorescence predicts incident type 2 diabetes, cardiovascular disease and mortality in the general.
- Metabolic effects of non-nutritive sweeteners.
- Cephalic phase insulin release in healthy humans after taste stimulation.
- Intermittent metabolic switching, neuroplasticity and brain health.
- Fructose, Sugar Consumption, and metabolic disorders.
- Microbiota associated with type 2 diabetes and its related complications
- Integrative Therapies for Anxiety-Microbiome
- Circadian clocks and insulin resistance.
- Week 10 Focus and Quiz Paper
- Metabolic Switching and your Brain
- Focus: Intermittent metabolic switching, neuroplasticity and brain health.
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- Finals Week Presentations
- Finals Week Recommended Papers of Interest
- Endocrine and metabolic link to coronavirus infection
- The epidemiology and pathogenesis of coronavirus disease-COVID-19-outbreak
- Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China
- Commentary-COVID-19 in Patients with Diabetes
- COVID-19 in Patients with Diabetes-Risk Factors That Increase Morbidity
- Finals Week Focus and Quiz Paper
- COVID-19 and your Metabolism.
- Focus: Endocrine and metabolic link to coronavirus infection
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