SDSU Systems Neuroscience


Marty Sereno — email: msereno - AT - sdsu
lecture recording times: Mon/Wed/Fri 9:00-9:50 AM (optional: Fri 8:00-8:50 AM)
lecture recording location: SSW 2667 (Learning Glass Studio, Student Services West)
All lectures recorded to Mediasite (first week also on zoom, link on canvas homepage)

Learning Glass lecture recordings
Neuroscience papers (background reading)
Sereno lecture notes (rough draft!) (168-page PDF [28MB] last update: 05 Mar 2021)
Neuroscience reference texts (not required):
    Squire, Berg et al., eds. (2008/2013) Fundamental Neuroscience, 3rd/4th ed.
    Kandel, Jessell, Schwartz, eds. (2008/2012) Principles of Neural Science, 5th/6th ed.
    Nieuwenhuys, Voogd, van Huijzen (2008) The Human Central Nervous System, 4th ed.
Neuroscience ugrad textbooks:
    Nicholls et al. (2012) From Neuron to Brain, 5th ed.
    Bear, Connors, and Paradiso (2006/2015) Neuroscience: Exploring the Brain, 3rd/4th ed.

multiple question short-answer, each question with a few subsections, examples given in lecture
2 midterms, final (midterms: 24% each, final: 32%), and short final paper (20%)
old pdf answer keys from my similar UCSD Systems Neuroscience course (2007) here and here

Learning Objectives:
Students will be able to do the following:
    (1) explain neuronal electrochemistry, development, evolution, relate to dendritic/Hebbian/attractor models
    (2) diagram neuroanatomical structures/connections low to high level in visual, somatosensory, auditory systems
    (3) analyze sequential processing stages in visual, somatosensory, and auditory systems from signals and systems view
    (4) diagram structures/connections in superior colliculus, cerebellum, striatum, motor cortex, and limbic system
    (5) describe neural models of eye movement planning, hierarchical motor control, organization of position/orientation
N.B.: consult with me if a disability hinders your performance so we can use University resources to maximize learning

Lecture Topics — Spring 2022 (1-page syllabus: pdf)

Week of Jan 17 (Wed/Fri - First class Jan 19)Introduction

[no class Mon]
introduction to course, folk theory of brain function
resting/Nernst/reversal potential
[no grad lecture]

Week of Jan 24 (Mon/Wed/Fri)Cellular Physiology

action potential, voltage-gated channels
voltage-sensitive dendritic currents, bursting
neurotrans.-gated post-synaptic potentials, NMDA, LTP/STDP
grad lecture: Hodgkin-Huxley, integrate-and-fire models

Week of Jan 31 (Mon/Wed/Fri)Relation to Neural Models

current flow in dendrites, equivalent circuits
simple Hebbian network model of orientation selectivity
simple attractor network model, energy analysis
grad lecture: covariance/eigenvector analysis of Hebbian learning

Week of Feb 07 (Mon/Wed/Fri)Neural Development

blastula, gastrula, neural plate, neural tube, optic cup
cylindrical coord system, temporal lobe formation, 'rule of Sereno'
later development, cortical subplate, gyrification
[no grad lecture]

Week of Feb 14 (Mon/Wed/Fri)Visual System I

retinal circuitry, origin of processing streams
retina to dLGN as a conformal map, layers
visual cortical maps: V1, V2, MT and the rest
grad lecture: cortical area development, achiasmatic sheepdog

Week of Feb 21 (Mon/Wed/Fri)Visual System II

cortical layer scheme, edges/brightness/motion in V1
V2 compartments, simple/complex/hypercomplex, 1st midterm review
1st Midterm Exam — Fri, Feb 25

Week of Feb 28 (Mon/Wed/Fri)Visual System III

Gabor filter model, aperture problems for color, pattern translation
aperture problem for complex motion, position invariance, contour analog
cortical-wide mechanisms of visual attention
grad lecture: explicit V1-to-MT model, Horn and Schunck

Week of Mar 07 (Mon/Wed/Fri)Somatosensory System

somatosensory receptor types, spinal cord
arm muscle diagram, ascending pathways: dorsal column, spinothalamic
somatosensory cortical areas, discontinuities, plasticity
grad lecture: smoothness constraint, line processes, stereo

Week of Mar 14 (Mon/Wed)Auditory System I

hair cell receptors, lateral line, electric fish
cochlear structure/transduction, 1D vs. 2D maps, mammalian brainstem
[no classes Fri]

Week of Mar 21 (Mon/Wed/Fri)Auditory System II

cochlear nuclei responses, auditory streams
nucleus laminaris coincidence detection
construction of the owl space map
grad lecture: auditory thalamus, cortex, freq vs. pitch

Week of Mar 28SPRING BREAK

[no class Mon]
[no class Wed]
[no class Fri]

Week of Apr 04 (Mon/Wed/Fri)Motor System I

bat echolocation and speech sound processing
gaze stabilization (VOR, OKN, pursuit)
superior colliculus retinal and motor maps, double-step remapping
grad lecture: bat FM, phonetics, auditory attention

Week of Apr 11 (Mon/Wed/Fri)Motor System II

multisensory map alignment: superior colliculus, VIP, LIP
motor system overview, spinal/brainstem pattern generators
motor cortex, 2nd midterm review
grad lecture: spatial->temp and temp->spatial, WTA, human VIP

Week of Apr 18 (Mon/Wed/Fri)Motor System III

2nd Midterm Exam — Mon, Apr 18
cerebellum: connections, microanatomy, learning
striatum: connectional/functional overview, hierarchical sequencing
grad lecture: origin of language I: vocal learning

Week of Apr 25 (Mon/Wed/Fri)Limbic System

connectional overview limbic system
hippocampus: H.M./intermediate term memory vs. inertial guidance
head direction and grid cells, attractor models
grad lecture: origin of language II: language and scenes

Week of May 02 (Mon/Wed)Neuroimaging MRI/EEG/MEG

source of EEG/MEG, MRI hardware, spin vs. precession, Bloch equation
Fourier transform, relation to MRI image formation
[TBA] course review

Mon, May 09, 8-10 AMFinal Exam

Final Exam
Graduate students: final paper due May 13

last modified: Jun 01, 2022
Scanned/video'd class notes (pdf, links above) © 2022 Martin I. Sereno
Supported by NSF 0224321, NIH MH081990, Royal Society Wolfson