SDSU Systems Neuroscience
SPRING 2022 (go
here
for current/latest version)
Professor:
Marty Sereno
— email: msereno - AT - sdsu
lecture recording times: Mon/Wed/Fri 9:00-9:50 AM (optional: Fri 8:00-8:50 AM)
lecture recording location:
SSW 2667
(Learning Glass Studio, Student Services West)
All lectures recorded to Mediasite (first week also on zoom, link on canvas homepage)
Resources:
Learning Glass
lecture recordings
Neuroscience papers (background reading)
Sereno lecture notes (rough draft!) (168-page PDF [28MB] last update: 05 Mar 2021)
Neuroscience reference texts (not required):
Squire, Berg et al., eds. (2008/2013)
Fundamental Neuroscience, 3rd/4th ed.
Kandel, Jessell, Schwartz, eds. (2008/2012)
Principles of Neural Science, 5th/6th ed.
Nieuwenhuys, Voogd, van Huijzen (2008)
The Human Central Nervous System, 4th ed.
Neuroscience ugrad textbooks:
Nicholls et al. (2012)
From Neuron to Brain, 5th ed.
Bear, Connors, and Paradiso (2006/2015)
Neuroscience: Exploring the Brain, 3rd/4th ed.
Exams:
multiple question short-answer, each question with a few subsections,
examples given in lecture
2 midterms, final (midterms: 24% each, final: 32%), and
short final paper (20%)
old pdf answer keys from my similar UCSD Systems Neuroscience
course (2007)
here and
here
Learning Objectives:
Students will be able to do the following:
(1) explain neuronal electrochemistry,
development, evolution, relate to dendritic/Hebbian/attractor models
(2) diagram neuroanatomical structures/connections
low to high level in visual, somatosensory, auditory systems
(3) analyze sequential processing stages in
visual, somatosensory, and auditory systems from signals and systems view
(4) diagram structures/connections in superior
colliculus, cerebellum, striatum, motor cortex, and limbic system
(5) describe neural models of eye movement planning,
hierarchical motor control, organization of position/orientation
N.B.: consult with me if a disability hinders your performance
so we can use University resources to maximize learning
Lecture Topics — Spring 2022
(1-page syllabus: pdf)
Week of Jan 17 (Wed/Fri - First class Jan 19) — Introduction
[no class Mon]
introduction to course, folk theory of brain function
resting/Nernst/reversal potential
[no grad lecture]
Week of Jan 24 (Mon/Wed/Fri) — Cellular Physiology
action potential, voltage-gated channels
voltage-sensitive dendritic currents, bursting
neurotrans.-gated post-synaptic potentials, NMDA, LTP/STDP
grad lecture: Hodgkin-Huxley, integrate-and-fire models
Week of Jan 31 (Mon/Wed/Fri) — Relation to Neural Models
current flow in dendrites, equivalent circuits
simple Hebbian network model of orientation selectivity
simple attractor network model, energy analysis
grad lecture: covariance/eigenvector analysis of Hebbian learning
Week of Feb 07 (Mon/Wed/Fri) — Neural Development
blastula, gastrula, neural plate, neural tube, optic cup
cylindrical coord system, temporal lobe formation, 'rule of Sereno'
later development, cortical subplate, gyrification
[no grad lecture]
Week of Feb 14 (Mon/Wed/Fri) — Visual System I
retinal circuitry, origin of processing streams
retina to dLGN as a conformal map, layers
visual cortical maps: V1, V2, MT and the rest
grad lecture: cortical area development, achiasmatic sheepdog
Week of Feb 21 (Mon/Wed/Fri) — Visual System II
cortical layer scheme, edges/brightness/motion in V1
V2 compartments, simple/complex/hypercomplex, 1st midterm review
1st Midterm Exam — Fri, Feb 25
Week of Feb 28 (Mon/Wed/Fri) — Visual System III
Gabor filter model, aperture problems for color, pattern translation
aperture problem for complex motion, position invariance, contour analog
cortical-wide mechanisms of visual attention
grad lecture: explicit V1-to-MT model, Horn and Schunck
Week of Mar 07 (Mon/Wed/Fri) — Somatosensory System
somatosensory receptor types, spinal cord
arm muscle diagram, ascending pathways: dorsal column, spinothalamic
somatosensory cortical areas, discontinuities, plasticity
grad lecture: smoothness constraint, line processes, stereo
Week of Mar 14 (Mon/Wed) — Auditory System I
hair cell receptors, lateral line, electric fish
cochlear structure/transduction, 1D vs. 2D maps, mammalian brainstem
[no classes Fri]
Week of Mar 21 (Mon/Wed/Fri) — Auditory System II
cochlear nuclei responses, auditory streams
nucleus laminaris coincidence detection
construction of the owl space map
grad lecture: auditory thalamus, cortex, freq vs. pitch
Week of Mar 28 — SPRING BREAK
[no class Mon]
[no class Wed]
[no class Fri]
Week of Apr 04 (Mon/Wed/Fri) — Motor System I
bat echolocation and speech sound processing
gaze stabilization (VOR, OKN, pursuit)
superior colliculus retinal and motor maps, double-step remapping
grad lecture: bat FM, phonetics, auditory attention
Week of Apr 11 (Mon/Wed/Fri) — Motor System II
multisensory map alignment: superior colliculus, VIP, LIP
motor system overview, spinal/brainstem pattern generators
motor cortex, 2nd midterm review
grad lecture: spatial->temp and temp->spatial, WTA, human VIP
Week of Apr 18 (Mon/Wed/Fri) — Motor System III
2nd Midterm Exam — Mon, Apr 18
cerebellum: connections, microanatomy, learning
striatum: connectional/functional overview, hierarchical sequencing
grad lecture: origin of language I: vocal learning
Week of Apr 25 (Mon/Wed/Fri) — Limbic System
connectional overview limbic system
hippocampus: H.M./intermediate term memory vs. inertial guidance
head direction and grid cells, attractor models
grad lecture: origin of language II: language and scenes
Week of May 02 (Mon/Wed) — Neuroimaging MRI/EEG/MEG
source of EEG/MEG, MRI hardware, spin vs. precession, Bloch equation
Fourier transform, relation to MRI image formation
[TBA] course review
Mon, May 09, 8-10 AM — Final Exam
Final Exam
Graduate students: final paper due May 13
last modified: Jun 01, 2022
Scanned/video'd class notes (pdf, links above) © 2022 Martin I. Sereno
Supported by NSF 0224321, NIH MH081990, Royal Society Wolfson