Cognitive Science 170
Natural and Artificial Symbol-Using Systems

Name: _________________________

SHORT PAPER #2:

Question: (3-6 pages). Hand in a printout on real paper. If you want to also send me electronic text, send bare ASCII, RTF, PDF, or PostScript (no HTML or MSWord!).

1. Imagine that one base pair in the protein-coding part of the DNA sequence of a cell has been changed into a different base pair. Trace the effects of this change into the metabolic network of the cell in the following way: briefly describe how the changed base pair might effect transcription and translation (the molecular biological senses of these words), and then protein folding and function.

You must outline the main stages by which a one-dimensional sequence of DNA symbol segments (bases) is transformed into a metabolic network of chemical reactions controlled by proteins and tell me a little bit about how and why proteins fold. Since you cannot possibly summarize all of modern molecular biology in 3 to 6 pages, and since I have not told you which gene was damaged, concentrate on the architecture of molecular information transfer and interpretation as you describe the major stages and parts that are involved.

due by Mon, 5/12/03 (was previous Fri!)